Evaluation of oxidative stress in experimental rabbit aneurysms.
- Author:
Li LI
1
;
Xin-jian YANG
;
Fan JIANG
;
Ai-hua LIU
;
Zhong-xue WU
;
Gregory J DUSTING
Author Information
- Publication Type:Journal Article
- MeSH: Aneurysm; classification; metabolism; Animals; Disease Models, Animal; Malondialdehyde; metabolism; Oxidative Stress; Rabbits; Reactive Oxygen Species; metabolism; Superoxide Dismutase; metabolism
- From: Acta Academiae Medicinae Sinicae 2006;28(5):707-709
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the roles of oxidative stress in the generation and development of aneurysms.
METHODSFive terminal aneurysms and 8 lateral aneurysms were rebuilt on rabbits, and 6 normal artery vessels were prepared as control. The levels of malondialdehyde (MDA), superoxide dismutase (SOD), and anti-reactive oxygen species unit (anti-ROS unit) were measured with chemical methods.
RESULTSThe levels of MDA in terminal and lateral aneurysms were (33.85 +/- 8.66) and (27.87 +/- 5.78) nmol/mg prot, respectively, which were significantly higher than (10.91 +/- 2.72) nmol/mg prot in control group (P < 0.01). The levels of SOD in terminal and lateral aneurysms were (28.30 +/- 3.58) and (33.00 +/- 8.09) U/mg prot, respectively, which were significantly lower than (127.27 +/- 38.72) U/mg prot in control group (P < 0.01). The levels of anti-ROS unit in terminal and lateral aneurysms were (47.86 +/- 5.00) and (62.64 +/- 13.87) U/ mg prot, respectively, which were significantly lower than (116.94 +/- 9.22) U/mg prot in control group (P < 0.01). No significant differences were shown between terminal aneurysm and lateral aneurysm in MDA and SOD except anti-ROS unit (P = 0.014). MDA had negative correlations with both SOD and anti-ROS unit, and the correlation coefficients were -0. 830 and -0. 852, respectively.
CONCLUSIONOxidative stress may play an important role in the development of aneurysms. Oxidative stress seems similar among various aneurysms.
