Relationship between cervical micrometastasis and early recurrence and prognosis in laryngeal carcinoma
10.3760/cma.j.issn.1673-0860.2012.04.004
- VernacularTitle:喉鳞状细胞癌颈淋巴结微小转移灶与早期复发及预后的关系
- Author:
Ya-Nan XU
1
;
Meng-Jia FEI
;
Jia-Dong WANG
;
Lu-Ying ZHENG
;
Yi-Ming CHEN
;
Qiang LIU
Author Information
1. 上海交通大学医学院附属仁济医院
- Keywords:
Laryngeal neoplasms;
Carcinoma,squamous cell;
Lymphatic metastasis;
Prognosis
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2012;47(4):280-284
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the correlation between the micrometastasis and early recurrence and prognosis in laryngeal cancer.Methods Total of 126 patients with laryngeal squamous cell carcinoma were included in the study.The micrometastasis was detected with hematoxylin and eosin staining(HE) and immunohistochemical staining for cytokeratin (CK) of the lymph node specimens after selective neck dissection( Ⅱ -Ⅳ).Chi-square test was used to analyse the relationship between the micrometastasis and early recurrence and prognosis,and Kaplan-Meier method was used for survival analysis.Results HE staining showed positive micrometastasis in 41 cases and negative micrometastasis in 85 cases in which 33 cases were positive staining for CK. With a following-up of mean 6.3 years,recurrence or metastasis occurred in 15 cases with positive micrometastasis detected by HE staining,14 cases with CK positive staining and 4 cases with CK negative staining.The correlation between micrometastasis and early recurrence was significant(P ＜ 0.01 ).The total 5-year survival rate was 79.8％,10-year survival rate was 60.5％.The 10-year survival rate(52.1％ ) of the patients with CK positive staining indicating micrometastasis was significantly higher than that of CK negative patients (81.2％,P ＜ 0.01 ). Conclusion Cervical micrometastasis predicts poor prognosis and early recurrence in patients with laryngeal squamous cell carcinoma.
