Prognostic analysis of 76 cases with adenoid cystic carcinoma in salivary gland
10.3760/cma.j.issn.1673-0860.2012.03.006
- VernacularTitle:涎腺腺样囊性癌76例预后因素分析
- Author:
Ming-Hua GE
1
;
Jia-Feng WANG
;
Qing-Min XIA
;
Zhuo TAN
;
Jia-Jie XU
;
Chao CHEN
;
Ke-Jing WANG
;
Xiang-Rong TAN
Author Information
1. 浙江省肿瘤医院
- Keywords:
Salivary gland neoplasms;
Carcinoma,adenoid cystic;
Radiotherapy;
Prognosis
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2012;47(3):202-206
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prognosis of adenoid cystic carcinoma (ACC) in salivary gland and its influencing factors.Methods Clinical and following-up data of 76 patients with ACC in salivary glands were reviewed. Major gland tumors represented 35.5％ whereas minor gland tumors comprised 64.5％ of the cohort,with 8 cases ( 10.5％ ) in stage I,23 (30.3％ ) in stage Ⅱ,18 (23.7％) in stage Ⅲ and 27 (35.5％) in stage Ⅳ. Survival rates were calculated by Kaplan-Merier method.Cumulative survival curves were evaluated using the Log-rank test. Multivariate analysis was performed by Cox proportional hazard model.Results The regional recurrence rate was 28.9％ and distant metastasis rate was 21.1％.The overall 5-year survival rate,tumor-free survival rate and tumor-related survival rate were 73.7％,61.8％ and 74.9％ respectively.The overall 10-year survival rate,tumor-free survival rate and tumor-related survival rate were 48.2％,39.8％ and 56.2％ respectively.Univariate survival analysis showed pathological type,clinical stage and perineural invasion were relevant to the prognosis of ACC and multivariate analysis showed they were the independent prognostic factors of ACC in salivary gland.Conclusions Clinical stage,pathological type and perineural invasion were the independent prognostic factors for adenoid cystic carcinoma in salivary gland. Surgery was the first choice for the treatment of adenoid cystic carcinoma in salivary gland,and postoperative radiotherapy may prolong the tumor-free survival time of patients in stage Ⅲ and Ⅳ.
