The Role of sICAM-1 Detection in the Diagnosis of Acute Rejection Following Liver Transplantation
- Author:
Yahong YU
1
;
Zhong CHEN
;
Qifa YE
Author Information
1. 华中科技大学同济医学院
- Keywords:
orthotopic liver transplantation;
acute rejection;
bile;
serum;
sICAM-1
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2006;26(5):580-582
- CountryChina
- Language:Chinese
-
Abstract:
In order to evaluate the applied value of soluble intracellular adhesion molecule-1 (sI-CAM-1) in acute rejection (AR) following liver transplantation, the expression of sICAM-1 protein was sequentially detected by using ELISA in serum and bile of 43 patients receiving liver transplantation. In AR group, the expression levels of sICAM-1 protein were increased 3 days before and immediately on the establishment of AR diagnosis, and there was significant difference in the expression of bile between AR group and control group (P＜0.01). After reversion of AR with hormone intensive therapy, there was significant difference in the sICAM-1 protein expression of serum and bile between AR group and control group. It was concluded that the sequential detection of sICAM-1protein level in serum and bile was a reliable and noninvasive method for the early diagnosis of AR after liver transplantation and was valuable to observe the curative effects of anti-AR therapy.
