Comparison of Properties of Tumor Necrosis Factor-α Converting Enzyme (TACE) and Some Matrix Metalloproteases (MMPs) in Catalytic Domains
- Author:
Yunbin ZHAO
1
;
Wenfang FENG
;
Yuzhen YANG
;
Lunjiang LING
;
Runsheng CHEN
Author Information
1. 华中科技大学
- Keywords:
tumor;
necrosis;
factor-;
converting;
enzyme;
matrix;
metalloprotease;
catalytic;
domain
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2006;26(6):637-639
- CountryChina
- Language:Chinese
-
Abstract:
The crystal structural data of TACE, MMP-1, MMP-2, MMP-3 and MMP-9 were obtained from PDB database, and then their catalytic domains' properties including conformation, molecular surface hydrophobicity and electrostatic potential were analyzed and compared by using Insight Ⅱ molecular modeling software. It was found that the conformation and molecular surface hydrophobicity of catalytic domains of TACE and MMPs were not obviously different, but the molecular surface electrostatic potential of catalytic domain of TACE and MMPs had obvious differences.The findings are helpful in the Rational Drug Design of TACE selective inhibitor.
