Effect of yiqi bushen granule on the peripheral CD4+ CD8high T-lymphocyte and natural killer cell in patients with minimal residual leukemia.
- Author:
Yong-Gang XU
1
;
Rou MA
;
Xiao-Hong YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; CD4-Positive T-Lymphocytes; immunology; CD8-Positive T-Lymphocytes; immunology; Disease-Free Survival; Drugs, Chinese Herbal; therapeutic use; Female; Humans; Killer Cells, Natural; immunology; Leukemia; drug therapy; immunology; Male; Middle Aged; Neoplasm, Residual; Phytotherapy; Survival Rate; Young Adult
- From: Chinese Journal of Integrated Traditional and Western Medicine 2010;30(6):571-574
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effect of Yiqi Bushen Granule (YBG) on CD4+ CD8high T lymphocyte in patients with minimal residual leukemia (MRL) and to probe its prognosis after treatment.
METHODSThe changes of CD4+ CD8high T lymphocyte subgroup and natural killer (NK) cells in 36 patients (16 males and 20 females) received long-term (> 3 months) YBG therapy before and after treatment were analyzed using multi-parameter flow cytometry and controlled by those in 34 healthy persons (19 males and 15 females).
RESULTSThe 3-year and 5-year complete remission rates in MRL patients were 75.0% and 63.9%; their 3-year and 5-year survival rates were 80.5% and 72.2%, respectively; as compared with the baseline, the absolute value and percentage of CD4+ CD8high T lymphocyte and NK cells were all significantly raised after treatment (P < 0.05 or P < 0.01).
CONCLUSIONYBG could prolong the disease-free survival in MRL patients by way of regulating the immune function of organism, elevating the amount of CD4+ CD8high T lymphocyte and NK cells to kill or suppress the residual leukemic cell in body.
