Effect of oleum fructus brucease injection via bronchial arterial infusion in treating advanced lung cancer.
- Author:
Zheng-ping BAI
1
;
Xiang-sheng DENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; therapeutic use; Bronchial Arteries; Brucea; chemistry; Carcinoma, Non-Small-Cell Lung; drug therapy; Drug Therapy, Combination; Female; Humans; Infusions, Intra-Arterial; Lung Neoplasms; drug therapy; Male; Middle Aged; Phytotherapy; Plant Oils; administration & dosage; Quality of Life; Seeds; chemistry
- From: Chinese Journal of Integrated Traditional and Western Medicine 2010;30(8):838-840
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the clinical effects of bronchial arterial infusion (BAI) with oleum fructus bruceae (OFB) Injection and chemotherapeutic agents (CTA) in treating advanced non-small cell lung cancer (NSCLC).
METHODSOne hundred and three patients with advanced NSCLC were randomized into 2 groups, the 98 patients in the treatment group treated by BAI with OFB + CTA and the 50 in the control group by BAI with CTA alone. The incidence of adverse reaction, change of tumor size and patients' quality of life (QOL) in the two groups were observed and compared.
RESULTSThe objective effective rate (CR + PR) was 63.3% in the treatment group and 46.0% in the control group (P < 0.01); the median survival duration in them was 363 days and 305 days; the 1-year cumulative survival rate was 70.4% and 44.0%, and the QOF improving rate was 83.7% and 62.0% respectively, the difference between groups were all statistically significant (P < 0.01). In addition, the incidence of adverse reactions of digestive symptoms, bone marrow suppression and the hepato-, renal and cardiac toxicities were lower in the treatment group than those in the control group (P < 0.01).
CONCLUSIONBAI with OFB + CTA in treating NSCLC could enhance the objective therapeutic effect of simple chemotherapy, as well as raise the QOL and protect immune and medulla function in patients.
