Effects of Chinese herbal compound for supplementing qi and activating blood circulation on actin, Cx43 expressions and gap junctional intercellular communication functions of myocardial cells in patients with Coxsackie virus B 3 viral myocarditis.
- Author:
Ming-xue ZHANG
1
;
Wei HE
;
Ping GU
Author Information
- Publication Type:Journal Article
- MeSH: Actins; genetics; metabolism; Animals; Animals, Newborn; Cell Communication; physiology; Connexin 43; genetics; metabolism; Coxsackievirus Infections; metabolism; Drugs, Chinese Herbal; pharmacology; Enterovirus B, Human; Gap Junctions; physiology; Myocarditis; metabolism; virology; Myocardium; metabolism; Rats; Rats, Wistar
- From: Chinese Journal of Integrated Traditional and Western Medicine 2010;30(8):880-883
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of Chinese herbal compound for supplementing qi and activating blood circulation (CHC) on the gap junctional intercellular communication (GJIC) function of myocardial cells in patients with Coxsackie virus B 3 (CVB3) viral myocarditis.
METHODSExpressions of actin and connexin43 (Cx43) in myocardial cells of patients arranged in three groups (the normal control group, the viral infected group and the CHC treated group) were detected by immunohistochemical method; the fluorescence photobleaching recovery rate of cells was detected by laser scanning confocal microscope.
RESULTSAs compared with the viral infected group, the expressions of actin and Cx43 were increased and the GJIC function was improved in the CHC treated group.
CONCLUSIONCHC could antagonize viral injury on skeleton protein, and repair the structure of gap junction channel to improve the GJIC function of myocardial cells after being attacked by CVB3.
