Viewing from the toll-like receptor/nuclear factor-kappaB signaling pathway to explore the immunomodulatory mechanism of Chinese drugs.
- Author:
Hong-guang ZHOU
1
;
Hai-bin CHEN
;
Mian-hua WU
Author Information
1. Nanjing University of Traditional Chinese Medicine, Nanjing.
- Publication Type:Journal Article
- MeSH:
Adjuvants, Immunologic;
pharmacology;
Drugs, Chinese Herbal;
pharmacology;
Humans;
NF-kappa B;
immunology;
Signal Transduction;
drug effects;
Toll-Like Receptors;
immunology
- From:
Chinese Journal of Integrated Traditional and Western Medicine
2010;30(8):884-888
- CountryChina
- Language:Chinese
-
Abstract:
Many Chinese drugs (CHD) have showed their significant effects of integral immune-regulation, and lots of researches have conducted in recent years for exploring their mechanism from different levels, like cytological, molecular and genetic levels. In this paper, the relation between immune-regulation of CHD and Toll-like receptors/nuclear factor-kappaB (TLRs/NF-kappaB) signaling pathway was introduced in brief based upon the achievements of previous researches. It was pointed out that the two are closely related, to explore mechanism of CHD in this way is meaningful not only for further deepening the theoretical understanding of CHD's pharmacological immunoregulation, but also be practically facilitate for enhancing therapeutic efficacy of CHD and developing new CHD.
