Study on the association of IL-10-592 polymorphism with susceptibility to hepatitis B viral infection in Han, Yi and Yao ethnic groups in Guizhou province
10.3321/j.issn:0254-6450.2008.05.007
- VernacularTitle:贵州省彝族、瑶族、汉族人群乙型肝炎病毒感染与白细胞介素-10-592多态性相关研究
- Author:
Chan-Juan WANG
1
;
Ke-Ren SHAN
;
Yan HE
;
Ting ZHANG
;
Yi LI
;
Xiao-Lan QI
;
Yan ZHAO
;
Yan XIAO
;
Chang-Xue WU
;
Zhi-Zhong GUAN
;
Xi-Lin REN
Author Information
1. 贵阳医学院
- Keywords:
Hepatitis B virus;
IL-10;
Gene polymorphism;
Minority
- From:
Chinese Journal of Epidemiology
2008;29(5):444-448
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of IL-10 gene promoter polymorphism with susceptibility to hepatitis B viral infection in Han, Yi and Yao ethnic groups from Guizhou province.Methods Five hundred volunteers from Guizhou province were selected to undertake PCR-RFLP for detection of IL-10 gene promoter -592 polymorphisim. Results The genotypic distributions of IL-10-592 were 32.53%- 51.43% (AA),40.74%-54.82% (AC),5.79%-18.52% (CC) whereas the allelic frequencies were 59.94% -72.38% for the A allele, and 27.62%-40.06% for the C allele in Han, Yi and Yao ethnics from Guizhou. The distributions of allele and genotype frequencies of IL-10-592 were statistically different between Yao ethnic in Libo and Yi ethnic in Qianxi, Yao ethnic in Libo and Han ethnic in Libo, Yi ethnic in Qianxi and Yi ethnic in Weining, Yi ethnic in Weining and Han ethnic in Libo (P ＜0.05). IL-10-592 polymorphism was associated with HBV infection in Yi ethnic in Qianxi and the whole population. Conclusion IL-10-592 gene polymorphisms influenced the susceptibility to HBV infection in Han, Yao, Yi sub-populations in Guizhou. Result of the study suggested that IL-10-592 gene polymorphisms might serve as a risk factor to HBV infection.
