Study on the correlation between CETP TaqIB,KCNE1 S38G and eNOS T-786C gene polymorphisms for predisposition and non-valvular atrial fibrillation
10.3321/j.issn:0254-6450.2008.05.016
- VernacularTitle:CETP TaqIB、KCNE1 S38G和eNOS T-786C基因多态性与非瓣膜性心房颤动的关联研究
- Author:
Li-Xin XU
1
;
Wei-Yu YANG
;
Huai-Qin ZHANG
;
Zhi-Hua TAO
;
Cheng-Cheng DUAN
Author Information
1. 温州医学院附属第一医院
- Keywords:
Non-valvular atrial fibrillation;
Multifactor dimensionality reduction;
Single nucleotide polymorphism;
Gene-gene interaction
- From:
Chinese Journal of Epidemiology
2008;29(5):486-492
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study whether CETP TaqIB,KCNE1 S38G and eNOS T-786C genetic polymorphisms are associated with non-valvular atrial fibrillation in the Han population from Zhejiang province.Methods Polymerase chain reaction restriction fragment length polymorphism assay was used to detect the distribution of alleles and genotypes of CETP TaqIB,KCNE1 S38G and eNOS T-786C in 147 patients with non-valvular atrial fibrillation and in 147 subjects as controls in Han population of Zhejiang province.Results (1)The frequency of CETP B1 allele in NVAF patients was higher than that of the control group and showing a statistically significant difference(OR=1.763,95%CI:1.247-2.492.P=0.002). (2) Results from logistic regression analysis revealed that: after adjustment of confounding variables such as sex,age,smoking,hypertension and body mass index,data from the binary logistic analysis showed a statistically significant difference in CETP TaqIB genetic polymorphism between Patients and controls.(3)From multifactor dimensionality reduction analysis,results showed an interaction of CETP TaqIB,KCNE1 S38G and eNOS T-786C genetic polymorphisms.Odds ratio of the three simultaneously existing genetic polymorphisms was 1.849 times more than CETP TaqIB alone.Conclusion CETP BI allele was an independent risk factor for predisposition to non- valvular atrial fibrillation.These findings suggested that the simultaneous existence of CETP B1,KCNE1 S38G and eNOS T-786C allele might be elevated with the predisposition to non-valvular atrial fibrillation in the Han population of Zhejiang province.
