Molecular epidemiological study on oxidative DNA damage among Hasake ethnic migrants in Shenzhen
10.3321/j.issn:0254-6450.2008.07.015
- VernacularTitle:深圳市新疆哈萨克族移民DNA氧化损伤的分子流行病学研究
- Author:
Yue-Bin KE
1
;
Jin-Quan CHENG
;
Zhi-Hong SHUAI
;
Ren-Li ZHANG
;
Gao-Feng JIANG
;
Chun-Rong TAN
;
Zun-Zhen ZHANG
Author Information
1. 深圳市疾病预防控制中心
- Keywords:
Migration;
Life style;
Comet assay;
8-hydroxy-2'-deoxyguanosine;
Hasake ethnic
- From:
Chinese Journal of Epidemiology
2008;29(7):683-684
- CountryChina
- Language:Chinese
-
Abstract:
objective To explore the relationship of migration and oxidative DNA damage by comparative study of oxidative DNA damage effects on people with difierent years of migration among Xinjiang Hasake ethnecity in Shenzhen.Methods Sixty Hasake residents in Shenzhen were selected,and were divided into three groups(n=20)according to the years of migration.Major changes of their life style were investigated.8-hydroxy-2'-deoxyguanosine(8-OH-dG)levels in urine were analyzed,and comet assay of peripheral blood lymphocytes conducted.Results When comparing with the group having a shorter than 1 year of stay,a significant decrease of oliveive tail moment and tail/head length in comet assay in the＞3 years group(P＜0.05)was observed 8-OH-dG level decreased significantly in 1-3 years group (P＜0.05)and＞3 years group(P＜0.01).Conclusion Our results suggested that life style changes which related to migration might reduce DNA damage in Hasake nationalities.
