Multivariate analysis on the relationship between polymorphisms on chromosome 17 and essential hypertension
10.3321/j.issn:0254-6450.2008.06.002
- VernacularTitle:17染色体微卫星多态与原发性高血压关系的多因素分析
- Author:
Ling-Yu FU
1
;
Yan-Yan ZHAO
;
Jing-Pu SHI
;
Chun-Yi LI
;
Hong LIU
;
Bo ZHOU
Author Information
1. 中国医科大学附属第一医院
- Keywords:
Essential hypertension;
Microsatellite;
Genetic susceptibility
- From:
Chinese Journal of Epidemiology
2008;29(6):522-525
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship of polymorphisms of D17S1878, D17S932 sites and essential hypertension.Methods Sixty-seven pedigrees were collected at the region with high prevalence of hypertension. The polymorphisms of D17S1878 and D17S932 sites were genotyped using Genetic Analyzer and GeneScan Software. Case-control study in sibs with different phenotype was carried out and logistic analysis was used for multivariate analysis. Results There were significant differences on the distributions of age, male, drinking, average systolic pressure, average diastolic pressure, the characteristics of rash, body mass index (BMI), total cholesterol amount, triglyceride, low density lipoprotein(LDL) between the hypertensive-affected sibs and the normotensive sibs (P＜0.05). There was significant difference between the affected hypertensive and normotensive sibs in the D17S1878 site (P＜0.05), while there was no significant difference in D17S932 (P＞0.05 ). After non-conditional logistic analysis, data showed that both sites were not included in the model, while age( OR = 1.044,95%CI:1. 019-1. 069), drinking ( OR = 2. 644,95% CI : 1. 778-3. 932), the characteristics of rash ( OR = 3. 078,95%CI:1.721-5.504), triglyceride (OR= 1.305,95%CI: 1.016-1.676), LDL-C (OR= 1.787,95% CI:1. 296-2. 646), as risk factors, were included in the model. Conclusion The polymorphisms of D17S1878 and D17S932 possibly were not associated with essential hypertension.
