Study on the association of predisposing genes with essential hypertension among Kazakhs ethnic group in Xinjiang.
- Author:
Xing-dong CHEN
1
;
Shu-mei WANG
;
Xiao-feng WANG
;
Ming LU
;
Li JIN
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; China; epidemiology; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Hypertension; ethnology; genetics; Middle Aged; Polymorphism, Genetic
- From: Chinese Journal of Epidemiology 2008;29(8):752-756
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between M235T and G-6A polymorphism of AGT gene, insertion/deletion (I/D) polymorphism of ACE gene, Gly460Trp polymorphism of ADD1 gene, C825T polymorphism of GNB3 gene and essential hypertension in Xinjiang Kazakhs group as well as to identify the interactions of gene-gene and gene-environment.
METHODSA case-control study (n = 441) was performed in 241 cases and 202 controls. Polymerase chain reaction and restrict fragment length polymorphism (PCR-PFLP) technique were used to detect the genotypes polymorphism.
RESULTSComparing the frequencies of alleles and genotypes, there were no statistical significances except frequency of allele of M235T (P = 0.0483) identified. In logistic regression analysis, there were significant differences in all of the loci. The 4 loci model (AGE/CHO/G-6A/ACE) appeared the best model in MDR analysis.
CONCLUSIONOur research data showed that the polymorphisms of all the four genes might be associated with hypertension in the Kazakhs group of Xinjiang while there might be interactions existed in AGT, ACE, AGE and CHO.
