Fertilization and Pregnancy Rate of Testicular Sperm after Testicular Sperm Extraction (TESE) with Intracytoplasmic Sperm Injection(ICSI).
- Author:
Yong Seog PARK
;
Ju Tae SEO
;
Jin Hyun JUN
;
Hye Kyung BYUN
;
Jong Hyun KIM
;
You Sik LEE
;
Il Pyo SON
;
Inn Soo KANG
;
Ho Joon LEE
- Publication Type:Original Article
- MeSH:
Azoospermia;
Embryonic Development;
Female;
Fertilization*;
Humans;
Oocytes;
Pregnancy Rate*;
Pregnancy*;
Sertoli Cell-Only Syndrome;
Sperm Injections, Intracytoplasmic;
Spermatogenesis;
Spermatozoa*
- From:Korean Journal of Fertility and Sterility
1997;24(1):101-109
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study was carried to determine the possibility of finding motile spermatozoa and fertilization, pregnancy rate after testicular sperm extraction(TESE) with ICSI in obstructive and non-obstructive azoospermic patients. In 154 cases(132 patients), obstructive azoospermia was 77 cases and non-obstructive azoospermia was 77 cases. In obstructive azoospermia, patients generally showed normal spermatogenesis and included vas agenesis(n=8), multiple vas obstruction(n=7), epididymal obstruction (n=54). Total of 982 retrieved oocytes were obtained and 84.4% were injected. The fertilization rates with 2 PN and cleavage rate were 72.5% and 62.3%, .respectively. 30 pregnancies(38.9%) were achieved and the ongoing pregnancies were 22 cases (28.6%). In non-obstructive azoospermia, patients showed hypospermatogenesis(n=49), maturation arrest(n=4), Sertoli cell only syndrome (n=24). The various stages of spermatogenic cell could be retrieved by TESE and could be reached normal fertilization and embryo development with ICSI. Total of 1072 retrieved oocytes obtained and 80.2% were injected. The fertilization rates with 2 PN and cleavage rate were 52.8% and 68.9%, respectively. 22 pregnancies(30.1%) were achieved and the ongoing pregnancies were 19 cases(26.0%). Conclusively, the combination of TESE with ICSI using testicular spermatozoa can achieve normal fertilization and pregnancy rate and effective method in obstructive and non-obstructive azoospermic patients.
