A study on the preparing of magnetic doxorubicin nanoparticles and its heat effect under a magnetic field.
- Author:
Feng SHI
1
;
Ming WU
;
Miaoqing ZHANG
Author Information
1. First Affiliated Hospital, Zhongshan University, Guangzhou 510080.
- Publication Type:Journal Article
- MeSH:
Chemistry, Pharmaceutical;
Doxorubicin;
chemistry;
Drug Compounding;
methods;
Electromagnetic Fields;
Hot Temperature;
Magnetics;
Microspheres;
Nanotechnology
- From:
Journal of Biomedical Engineering
2003;20(3):463-465
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this research report is to introduce a method of making Doxorubicin magnetic nanoparticles for tumor treatment and to evaluate its heat effect under 100 KHz magnetic field. The preparing of the nanoparticles was carried out by stirring with supersonic mixer and cold drying. The shape and diameter of the nanoparticles were observed by penetrating electron microscopy. The nanoparticles were spherical in shape, and most of them were 200 nm in diameter. The changes of the temperature under a magnetic field in agarose gel and distilled water were measured respectively. The temperature went up with the increase of the amount of nanoparticles and the magnetic field intensity. The temperature finally remained constant due to the balance of heat generation and its transfer to the surroundings. The heat transfer was faster in water in the agarose gel.
