Immunohistochemical Study of bcl - 2 Expression in Basal Cell Carcinoma.
- Author:
Sun Young LEE
;
Kyu Chul CHOI
- Publication Type:Original Article
- Keywords:
Basal cell carcinoma, bcl-2
- MeSH:
Adenoids;
Animals;
Apoptosis;
Carcinogenesis;
Carcinoma, Basal Cell*;
Cell Death;
Mice
- From:Korean Journal of Dermatology
1997;35(2):242-248
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Basal cell carcinoma(BCC) is the most common tumor of light-skinned people. Most of them are relatively innocuous, but some may cause extensive tissue destruction, and result in death by local infiltration of vital structure or metastatic disease. The bcl-2 is a protooncogene involved in tumorigenesis by blocking apoptosis or programmed cell death. OBJECTIVE: To investigate whether there was a difference in bcl-2 expression in different histopathological types of BCC. Method: We performed immunohistochemical staining by using a monoclonal mouse anti-human bcl-2 oncoprotein in 28 BCC(nodular: 7 cases, micronodular; 3 cases, adenoid; 1 case, infiltrative; 9 cases, and mixed; 8 cases). Result: All 28 BCC expressed bcl-2, and the degree of staining was different according to histopathological types; poor prognostic micronodular(100%) and infiltrative(73.3%) types were relatively strong, and nodular(66.7% ) and adenoid(75.0%) types were moderate. Conclusion . These results suggest that the degree of bcl-2 expression in BCC seems to be dependent to the histopathological types together with clinical behavior.
