Study on relative bioavailability of aspirin in afenca tablet.
- Author:
Junyi YANG
1
;
Xuehua JIANG
;
Lin HE
;
Jing ZHOU
;
Suhua LI
;
Shu LIN
Author Information
1. School of Pharmacy, Sichuan University, Chengdu 610041.
- Publication Type:Journal Article
- MeSH:
Administration, Oral;
Adult;
Area Under Curve;
Aspirin;
administration & dosage;
pharmacokinetics;
Cross-Over Studies;
Humans;
Male;
Salicylic Acid;
blood;
Tablets;
Therapeutic Equivalency
- From:
Journal of Biomedical Engineering
2003;20(4):661-663
- CountryChina
- Language:Chinese
-
Abstract:
Salicylic acid is a kind of active metabolite of aspirin in vivo. In this study, its concentration in plasma was detected by RP-HPLC after twenty four healthy male volunteers were given each a single dose of oral Afenca test and reference preparations. The experiment data were calculated with 3P97 program. The results were analyzed by ANOVA and two- and one-sided t tests. The relative bioavailability of salicylic acid was 105.36% +/- 14.15%; AUC0-T of salicylic acid of test and reference preparations were 103.10 +/- 11.92 micrograms.h/ml and 98.45 +/- 13.49 micrograms.h/ml respectively; Tmax were 1.5 +/- 0.5 h and 1.5 +/- 0.5 h; Cmax were 19.31 +/- 2.47 micrograms/ml and 18.95 +/- 2.49 micrograms/ml. Bioequivalent evaluation of two preparations by analyzing with two- and one-sided t tests showed that the two preparations were bioequivalent on the basis of salicylic acid (t1 > or = t1-0.05(22), t2 > or = t1-0.06(22)).
