Pharmacokinetics of scutellarin in rabbits.
- Author:
Suhua LI
1
;
Xuehua JIANG
;
Qiang YANG
;
Zhaohui JIN
Author Information
1. West China School of Pharmacy, Sichuan University, Chengdu 610041.
- Publication Type:Journal Article
- MeSH:
Animals;
Apigenin;
Chromatography, High Pressure Liquid;
methods;
Female;
Flavonoids;
administration & dosage;
blood;
pharmacokinetics;
Glucuronates;
blood;
Injections, Intravenous;
Male;
Rabbits
- From:
Journal of Biomedical Engineering
2003;20(4):692-694
- CountryChina
- Language:Chinese
-
Abstract:
An RP-HPLC was established to determine scutellarin in rabbit plasma and to study pharmacokinetics of breviscapine in rabbits. The analytical column was DiamonsilTM C18(4.6 mm x 250 mm, 5 microns), the mobile phase consisted of methanol, 0.02 mol/L phosphate buffer(adjusted by phosphoric acid to pH 3.0) and acetonitrile (65:35:10), the flow rate was 1.0 ml.min-1, the column temperature was 25 degrees C and the detection wavelength was 334 nm. The results of the pharmacokinetics study showed that the concentration-time curve of scutellarin was conformed to two-compartment model, the chief pharmacokinetic parameters were as follows: t1/2 alpha 1.29 +/- 0.53 min, t1/2 beta 10.40 +/- 1.97 min, Vc148.1 +/- 118.6 ml, and CL 57.5 +/- 31.7 ml.min-1.
