Study on a new antarthritic injection--O-carboxymethyl chitosan.
- Author:
Qiaoling HU
1
;
Zhongming ZHANG
;
Ming ZHANG
;
Gende GAO
Author Information
1. Institute of Polymer Composites, Zhejiang University, Hangzhou 310027, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Arthritis, Experimental;
drug therapy;
pathology;
Cartilage, Articular;
drug effects;
Cell Proliferation;
drug effects;
Chitosan;
administration & dosage;
analogs & derivatives;
therapeutic use;
Female;
Fibroblasts;
drug effects;
Injections, Intra-Articular;
Knee Joint;
drug effects;
Male;
Rabbits
- From:
Journal of Biomedical Engineering
2004;21(1):25-27
- CountryChina
- Language:Chinese
-
Abstract:
A type of water-soluble carboxymethyl chitosan (O--CMC), with 76% degree of substitution determined by conductivity method, was prepared by using chloroacetic acid to react with C6-OH of chitosan. The solubility of O--CMC was characterized also. Animal experiment in rabbits showed that O--CMC could lubricate arthron, inhibit proliferation of fibroblast cells on rabbits' knee joints, benefit the process of repairing pathologic articular cartilage, and produce good therapeutic effect on rheumatoid arthritis.
