An experiment to study the treatment of sarcomas by electroporation.
- Author:
Hong ZHANG
1
;
Baoyi WANG
;
Haichuan CHEN
;
Zishu WANG
;
Kong YANG
;
Jingru SUN
Author Information
1. School of Electronic Engineering and Information, Sichuan University, Chengdu 610064, China. scu.zh@sohu.com
- Publication Type:Journal Article
- MeSH:
Animals;
Antineoplastic Agents;
therapeutic use;
Apoptosis;
drug effects;
Cell Line, Tumor;
Cyclophosphamide;
therapeutic use;
Electrochemotherapy;
methods;
Mice;
Neoplasm Transplantation;
Sarcoma 180;
drug therapy;
pathology
- From:
Journal of Biomedical Engineering
2004;21(1):69-71
- CountryChina
- Language:Chinese
-
Abstract:
In this paper is reported a new approach for the treatment of sarcoma--electroporation therapy. Electroporation can accelerate pharmacal molecules into cytoplasm by transient electromagnetic pulses. We have utilized the phenomenon of electroporation treating the S-180 sarcomas in the hind legs of the Kunming mice by intratumoral injection of anti-tumor agent at low dose. From the experiment, we learned that this approach can bring about remarkable effect. The technical procedure is easy to do and easy to control. Especially, it is useful in curing the flat tumor and has little untoward side effect. It deserves to be recommended as a new approach to treating the tumor in clinics.
