Metabolic changes in abnormal savda patients with different types of tumor: a clinical observation.
- Author:
Yin CHEN
;
Mei-Zuo ZHONG
;
Halmurat UPUR
;
Batur MAMTIMIN
;
Wan-Li DENG
;
Rui WANG
;
Kamilijiang MAYILA
- Publication Type:Journal Article
- MeSH: Discriminant Analysis; Humans; Least-Squares Analysis; Lipids; blood; Magnetic Resonance Spectroscopy; Metabolome; physiology; Metabolomics; Neoplasms; metabolism
- From: Chinese Journal of Integrated Traditional and Western Medicine 2014;34(5):549-553
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore in vivo metabolic changes in abnormal savda patients with different types of tumor.
METHODSA total of 142 abnormal savda patients with common cancer types were enrolled in this study, and 50 healthy volunteers were recruited as the control group. For each sample, the H Nuclear Magnetic Resonance (NMR) based metabonomic analysis was performed. The free attenuation signal was computed subsection integral. Data obtained were analyzed by the Orthogonal Partial Least-Squares Discriminant Analysis (OPLS-DA).
RESULTSCompared with the control group, leucine, isoleucine, valine, histidine, phenylalanine, tyrosine, alanine, creatine, lactic acid, inositol, alpha-and beta-glucose, unsaturated lipids, very low density lipoprotein (VLDL) significantly decreased (P <0.05), while glycoprotein and carnitine significantly increased (P <0. 05) in the abnormal Savda group.
CONCLUSIONAbnormal savda patients with different types of tumor had similar metabonomics changes.