Different courses of esomeprazole-based triple therapy for Helicobactor pylori infection in children.
- Author:
Li XIANG
1
;
Fei-Qiu WEN
;
Wei-Hua ZUO
;
Yi TANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Amoxicillin; administration & dosage; Anti-Bacterial Agents; adverse effects; Anti-Ulcer Agents; administration & dosage; Child; Child, Preschool; Clarithromycin; administration & dosage; Drug Therapy, Combination; Esomeprazole; administration & dosage; Female; Helicobacter Infections; drug therapy; Helicobacter pylori; Humans; Male
- From: Chinese Journal of Contemporary Pediatrics 2007;9(3):205-206
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the efficacy of esomeprazole-based 1 week or 2 weeks triple therapy for Helicobactor pylori (H. pylori) infection in children.
METHODSOne hundred and five children with H. pylori infection identified by 13C-UBT were randomly assigned into Group A (n=60) and Group B (n=45). The patients of the two groups were administered with 1 week or 2 weeks triple therapy consisting of esomeprazole, clarithromycin and amoxillin, respectively. They were followed up four weeks after drug withdrawal.
RESULTSRecurrent abdominal pain was relieved in all of patients. Fifty-five patients (91.7%) showed 13C-UBT negative in Group A and 42 (93.3%) presented negative in Group B. There was no significant difference in the eradication rate of H. pylori.
CONCLUSIONSEsomeprazole-based triple therapy for H. pylori infection is effective in children. The efficacy of esomeprazole-based 1 week or 2 weeks triple therapy for this disorder does not appear to be different.
