Expression of Stat3, HIF-1alpha and VEGF in Wilms' tumor.
- Author:
Zhi-Bin NIU
1
;
Chang-Lin WANG
;
Ying HOU
;
Yi YANG
;
Hong GAO
Author Information
- Publication Type:Journal Article
- MeSH: Child; Child, Preschool; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; analysis; Immunohistochemistry; Infant; Kidney Neoplasms; blood supply; chemistry; pathology; Male; Neoplasm Staging; Neovascularization, Pathologic; etiology; STAT3 Transcription Factor; analysis; Vascular Endothelial Growth Factor A; analysis; antagonists & inhibitors; Wilms Tumor; blood supply; chemistry; pathology
- From: Chinese Journal of Contemporary Pediatrics 2007;9(5):461-464
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expression of signal transducer and activator of transcription 3 (Stat3), hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) in Wilms' tumor and their roles in the development of Wilms' tumor.
METHODSThe expression of Stat3, HIF-1alpha and VEGF were detected by the immunohistochemical staining in 52 specimens from Wilms' tumor tissues, 47 from adjacent kidney tissues and 8 from normal kidney tissues. The expression intensity was analyzed by computer image processing.
RESULTSThe expression of Stat3, HIF-1 and VEGF were significantly up-regulated in Wilms' tumor tissues compared to those in adjacent tissues and normal kidney tissues (P < 0.05). Stat3 and VEGF proteins in Wilms' tumor tissues of stage III-IV and high risk histopathology were significantly higher than those of stage I-II and low risk histopathology. The higher expression of HIF-1 in Wilms' tumor tissues was shown in tumors with high risk histopathology and tumor size > or = 6 cm.
CONCLUSIONSIncreased expression of Stat3, HIF-1 and VEGF were found in Wilms' tumor tissues, and may be related to the development and angiogenesis of Wilms' tumor. Stat3 may regulate the expression of HIF-1 and VEGF, so it could be an effective target for inhibiting VEGF expression and angiogenesis of Wilms' tumor.
