Inhibitory activities of 3-trifluoromethyl benzamide derivatives against the entry of H5N1 influenza viruses.
- Author:
Zhibo ZHU
1
;
Yun CAI
;
Jie YANG
;
Xianglian LI
;
Runming LI
;
Shuwen LIU
Author Information
- Publication Type:Journal Article
- MeSH: Antiviral Agents; pharmacology; Benzamides; pharmacology; Humans; Influenza A Virus, H5N1 Subtype; drug effects; physiology; Influenza, Human; Virus Internalization; drug effects
- From: Journal of Southern Medical University 2014;34(7):961-964
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the inhibitory activities of 3-trifluoromethyl benzamide derivatives against the entry of H5N1 influenza viruses.
METHODSThe lead compound was structurally modified to obtain 3 compounds with inhibitory activities against H5N1 influenza viruses. Specs compound librany was screened and 4 compounds were identified to have such inhibitory activities. The inhibitory activities of these compounds were tested at a celluar level against H5N1 influenza viruses.
RESULTS AND CONCLUSIONThe compounds 1a, 1b, 1e and 1f showed signifcant inhibitory activities against the entry of A/AnHui/1/2005 pseudovirus into the target cells with an IC50 value of 4.7 ± 0.3 µmol/L.
