Effect of statins on occurrence of infection and infection-related mortality: a meta-analysis.
- Author:
Guizuo WANG
1
;
Yonghong ZHANG
;
Xinming XIE
;
Dong HAN
;
Yuanyuan WU
;
Shaojun LI
;
Fengjuan LI
;
Manxiang LI
Author Information
- Publication Type:Journal Article
- MeSH: Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; therapeutic use; Infection; epidemiology; mortality; Randomized Controlled Trials as Topic; Risk Factors
- From: Journal of Southern Medical University 2014;34(7):988-993
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo systematically review whether statins can reduce the risk of infection and infection-related mortality.
METHODSWe searched the Cochrane Library, MEDLINE, EMBASE, PubMed, Elsevier and CBM databases for randomized placebo-controlled trials of statins published by September 2013, and each trial enrolled at least 100 participants with follow-up for at least 4 weeks. Two reviewers independently assessed the quality of the included studies and extracted the relevant data for analysis using Stata 12.0 software.
RESULTSSixteen trails involving a total of 48973 patients were included in our meta-analysis. The results showed that statins significantly reduced the risk of infection (OR=0.93, 95% CI 0.89 to 0.98, P=0.004) compared to placebo but did not significantly lower infection-related mortality (OR=0.96, 95% CI 0.82 to 1.12, P=0.592).
CONCLUSIONStatins can significantly reduce the risk of infection but does not lower infection-related mortality.
