Intraoperative methylene blue and (99m)Tc-sulfur colloid isotope tracing for sentinel node mapping in early-stage non-small cell lung cancer.
- Author:
Bin HONG
1
;
Xueyuan SHEN
;
Jiangyong CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma, Non-Small-Cell Lung; diagnosis; Colloids; Humans; Immunohistochemistry; Isotopes; Lymph Node Excision; Lymph Nodes; pathology; Lymphatic Metastasis; diagnosis; Methylene Blue; Sentinel Lymph Node Biopsy; Sulfur; Technetium Tc 99m Sulfur Colloid
- From: Journal of Southern Medical University 2014;34(7):1053-1056
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the accuracy of intaoperative methylene blue alone and in combination with (99m)Tc-sulfur colloid isotopic tracing for detection of sentinel lymph nodes (SLNs) in early-stage non-small cell lung cancer (NSCLC).
METHODSSixty-one patients with operable NSCLC who did not receive previous radiotherapy or chemotherapy were enrolled. Methylene blue and (99m)Tc-sulfur colloid were injected into the subserosal layer adjacent to the tumor, and SLNs were defined as those with blue staining or those containing 3 times more radioactivity than the surrounding tissue detected with a gamma probe. The SLN were removed with systematic lymph node dissection. All the removed lymph nodes were examined histopathologically with HE staining and immunohistochemistry.
RESULTSMethylene blue alone showed a low detection rate (60.0%) and sensitivity (58.33%) for SLNs compared with the combination of methylene blue and isotope tracing (96.15% and 92.86%, respectively).
CONCLUSIONThe combination of methylene blue and (99m)Tc-sulfur colloid isotopic tracing allows accurate detection of the SLNs in early-stage NSCLC.
