Dynamic changes of tear fluid matrix metralloproteinase-9 within 1 year after laser in situ keratomileusis.
- Author:
Hongpei JI
1
;
Aiwei CHEN
;
Weiwei ZHANG
;
Hong GU
;
Zhiling ZHANG
;
Juqin FU
Author Information
- Publication Type:Journal Article
- MeSH: Cornea; Humans; Keratomileusis, Laser In Situ; Matrix Metalloproteinase 9; chemistry; Myopia; surgery; Postoperative Period; Prospective Studies; Tears; chemistry; Wound Healing
- From: Journal of Southern Medical University 2014;34(8):1079-1082
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the dynamic changes of matrix metalloproteinase-9 (MMP-9) level in tear fluid within 12 months after laser in situ keratomileusis (LASIK).
METHODSTwenty-two myopic patients undergoing uneventful LASIK were enrolled in this study. Tear fluid samples were collected from the patients for measurements of MMP-9 level using Western blotting preoperatively, at 7 and 14 days, and at 1, 2, 3, 6, and 12 months after the surgery.
RESULTSMMP-9 concentrations in the tear fluid of post-LASIK patients showed a time-dependent variation pattern. MMP-9 reached its peak level in the tear fluid at 14 days postoperatively, which was 2.70 times the preoperative level; it gradually decreased thereafter but was still 1.38 times the preoperative level at 12 months after the surgery.
CONCLUSIONSMMP-9 concentrations in the tear fluid of post-LASIK patients show a time-dependent variation pattern and remains higher than the preoperative level even at 12 months after the surgery, suggesting that corneal wound healing after LASIK lasts for more than 12 months.
