Resting-state functional magnetic resonance imaging of first-onset major depressive disorder: analysis of 18 cases.
- Author:
Mouying GUO
1
;
Shuixing ZHANG
;
Mingzhi XU
;
Xueyu HU
;
Chengjia YANG
;
Wenbo CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Amygdala; Brain; physiopathology; Case-Control Studies; Cerebellum; Cognition; Depressive Disorder, Major; diagnosis; Emotions; Frontal Lobe; Humans; Magnetic Resonance Imaging; Temporal Lobe
- From: Journal of Southern Medical University 2014;34(9):1277-1281
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the changes in brain regional homogeneity in first-onset major depressive disorders (MDDs) using resting-state functional magnetic resonance imaging (fMRI).
METHODSEighteen patients with first-onset MDDs and twenty gender- and age-matched healthy controls underwent resting-state fMRI scans to compare the regional homogeneities of the brain regions.
RESULTSCompared with the normal controls, the patients with MDDs showed significantly decreased regional homogeneity in the left posterior cingulated gyrus, bilateral inferior temporal gyrus, bilateral superior temporal gyrus, left inferior frontal gyrus, left hippocampa gyrus, left posterior central gyrus, left angular gyrus, right amygdala, right orbital frontal gyrus, right supplementary motor area, and right cerebellar lobe.
CONCLUSIONPatients with first-onset MDDs have dysfunctions in the brain regions closed related with cognition and emotional control.
