Esophagus, Stomach & Intestine; Fundic Gland Polyps: A Clinical and Pathologic Analysis with Special Reference to Familial Adenomatous Polyposis.
- Author:
Yong Il KIM
;
Woo Ho KIM
;
In Sung SONG
;
Na Young KIM
;
Dong Ho LEE
;
Kyu Wan CHOI
;
Kook Lae LEE
;
Mee Soo CHANG
;
Ghee Young CHOE
- Publication Type:Original Article
- Keywords:
Fundic gland polyp(s);
Familial adenomatous polyposis;
Hyperplastic / hamartomatous fundic glandular proliferation
- MeSH:
Adenomatous Polyposis Coli*;
Biopsy;
Esophagus*;
Humans;
Intestines*;
Mucins;
Polyps*;
Stomach*
- From:Korean Journal of Gastrointestinal Endoscopy
1997;17(2):133-142
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: The aims of this study are to clarify the morphology of fundic gland polyp (FGP) and to compare the features of FGP between familial adenomatous polyposis-associated group and sporadic development group. METHODS: A total of 15 endo- scopic biopsy specimens of FGP from 13 patients were divided into three groups; Group A(3 cases; familial adenomatous polyposis family, multiple FGPs), Group B(3 cases; sporadic development, multiple FGPs) and Group C(7 cases; sporadic development, single FGP), and their endoseopic /microscopic features including mucin histochemistry and immunohistoc- hemistty(for PCNA) were compared. RESULTS: FGPs were confined to the gastric body and fundus in all 3 groups, and measured 2-8 mm. Their numbers varied even in Group A and Group B, The difference was observed in their median age: 26 years in Group A and 55 years in Group B, respectively, but there were no differences in endoscopic, histologic, mucin histochemical and immunohistochemical(for PCNA) features. Micro-scopically, all FGPs were composed of fundic glands and scattered microcysts with a spectrum of disordered glandular architecture which ranged from convoluted gland to Y-shaped gland, to stellateshaped gland, and to irregular tortuous glancl with dilated lumen. CONCLUSIONS: We assume that diversity af morphologic features of FGP may develop from progression of hyperplastic/hamartomatous fundic glandular proliferation which may end up with microcyst formation as an evolutional change. Familial adenomatous polyosis-associated FGPs were not endoscopically and histologically distingishable from sporadic deveoped FGPs.
