Ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance angiography combined with inflammatory factors for detecting atherosclerotic plaques in rabbits.
- Author:
Gongxin LI
1
;
Luzhao WANG
;
Peng LIU
;
Zhibo WEN
;
Fanheng HUANG
;
Liheng CHEN
;
Xin ZHAO
;
Lin LIN
;
Yijun ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Atherosclerosis; Contrast Media; Dextrans; Interleukin-10; analysis; Interleukin-6; analysis; Magnetic Resonance Angiography; Magnetite Nanoparticles; Male; Plaque, Atherosclerotic; diagnosis; Rabbits
- From: Journal of Southern Medical University 2014;34(9):1324-1328
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the feasibility of Ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance angiography (USPIO-MRA) combined with interleukin-6 (IL-6) and IL-10 detection for detecting atherosclerotic plaques in rabbits.
METHODSTwenty-four normal male rabbits were randomly assigned (n=8) into group A with atherosclerosis induced by damaging the aortic tunica intima with Foley's tube in combination with a high fat diet, group B with a high fat diet, and group C without any intervention. At week 12, plain and USPIO-MRA was performed in all the 24 rabbits and the results were compared with pathological examinations; blood samples were collected from the ear vein to examine blood lipids and levels of IL-6 and IL-10.
RESULTSThe rabbits in groups A and B showed significantly different IL-6 levels (167 ± 21.3 vs 116 ± 14.3 pg/ml, P<0.05) but comparable blood lipids and IL-10 levels (P>0.05). The levels of IL-6, IL-10, TC, TG, and LDL, but not HDL, differed significantly between groups A and C and between groups B and C (P<0.01). Continuous MRA scan showed significantly different signal-to-noise ratios (SNR) between the 3 groups.
CONCLUSIONUSPIO-MRA combined with IL-6 and IL-10 detection is feasible in detecting atherosclerotic plaques in rabbits.
