Value of different biochemical markers in early diagnosis of acute myocardial infarction.
- Author:
Yarong WANG
1
;
Zhuangbo GUO
;
Liping HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Acute Disease; Biomarkers; blood; Creatine Kinase, MB Form; blood; Early Diagnosis; Fatty Acid Binding Protein 3; Fatty Acid-Binding Proteins; blood; Humans; Myocardial Infarction; diagnosis; Sensitivity and Specificity; Troponin T; blood
- From: Journal of Southern Medical University 2014;34(9):1347-1350
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the value of the biochemical markers heart fatty acid binding protein (H-FABP), creatine kinase isoenzyme-MB (CK-MB), myocardial troponin T (cTnT) in early diagnosis of acute myocardial infarction (AMI).
METHODSSerum levels of H-FABP, CK-MB, and cTNT were detected in 95 patients with confirmed AMI at different time points following the onset in comparison with the data from 43 patients without AMI. The sensitivity and specificity of H-FABP in different phases following the onset were compared between those of CK-MB and cTnT.
RESULTSSerum H-FABP activities increased significantly within 3 h after the onset of AMI (P<0.01) and continued to increase at 3-6 h and 6-12 h (P<0.001). Serum level of CK-MB within 6 h and cTnT level within 3 h after AMI onset did not show obvious changes (P<0.05). Both the diagnostic sensitivity and specificity of H-FABP within 3 h and within 3-6 h were higher than those CK-MB and cTnT (P<0.05).
CONCLUSIONH-FABP is superior to CK-MB and cTnT in early diagnosis (within 3 h and 3-6 h following the onset) of AMI.
