Analgesic, anti-inflammatory and anti-diarrheal activities of ethanolic leaf extract of Typhonium trilobatum L. Schott.
- Author:
Khadem ALI
1
,
2
;
Ayesha ASHRAF
;
Nripendra Nath BISWAS
Author Information
- Publication Type:Journal Article
- Keywords: Analgesic; Anti-diarrheal; Anti-inflammatory; Toxicity; Typhonium trilobatum
- MeSH: Analgesics; chemistry; pharmacology; Animals; Anti-Inflammatory Agents; chemistry; pharmacology; Antidiarrheals; chemistry; pharmacology; Diarrhea; chemically induced; drug therapy; Disease Models, Animal; Edema; chemically induced; drug therapy; Female; Magnoliopsida; chemistry; Male; Mice; Phytochemicals; chemistry; Plant Extracts; chemistry; pharmacology; Plant Leaves; chemistry; Rats; Toxicity Tests, Acute
- From:Asian Pacific Journal of Tropical Biomedicine 2012;2(9):722-726
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo explore the efficacy of ethanolic leaf extract of Typhonium trilobatum L. Schott in treating diarrhea, pain and inflammation using experimental models.
METHODSIn the present study, acetic acid-induced writhing, xylene-induced ear edema and castor oil-induced diarrheal model were used to evaluate the analgesic, anti-inflammatory and anti-diarrheal activities, respectively. Acute toxicity test was carried out to fix the safe doses of the plant extract.
RESULTSThe plant extract demonstrated a significant inhibition of writhing (P<0.01) compared with the control group in acetic acid-induced writhing test in mice. The extract also significantly inhibited the xylene induced ear edema formation (P<0.05). In anti-diarrheal test, the extract significantly decreased the frequency of defecation and increased the mean latent period (P<0.01) in castor oil-induced diarrheal model mice at the doses of 250 and 500 mg/kg body weight.
CONCLUSIONSThese results suggest that the extract possesses significant analgesic, anti-inflammatory and anti-diarrheal activities that support to the ethnopharmacological uses of this plant.
