RNAi: antiviral therapy against dengue virus.
10.1016/S2221-1691(13)60057-X
- Author:
Sobia IDREES
1
;
Usman A ASHFAQ
Author Information
1. Department of Bioinformatics and Biotechnology, Government College University (GCU), Faisalabad, Pakistan.
- Publication Type:Journal Article
- Keywords:
Dengue haemorrhagic fever;
Dengue virus;
RNA interference;
Small interference RNA
- MeSH:
Animals;
Dengue;
therapy;
Dengue Virus;
genetics;
Humans;
RNA Interference;
RNA, Small Interfering;
genetics;
therapeutic use
- From:Asian Pacific Journal of Tropical Biomedicine
2013;3(3):232-236
- CountryChina
- Language:English
-
Abstract:
Dengue virus infection has become a global threat affecting around 100 countries in the world. Currently, there is no licensed antiviral agent available against dengue. Thus, there is a strong need to develop therapeutic strategies that can tackle this life threatening disease. RNA interference is an important and effective gene silencing process which degrades targeted RNA by a sequence specific process. Several studies have been conducted during the last decade to evaluate the efficiency of siRNA in inhibiting dengue virus replication. This review summarizes siRNAs as a therapeutic approach against dengue virus serotypes and concludes that siRNAs against virus and host genes can be next generation treatment of dengue virus infection.
