Expression and clinical significance of Claudin-1 and Claudin-4 in colorectal cancer tissues.
- Author:
Lin WANG
1
;
Shi-yong LI
;
Ping AN
;
Hui-yun CAI
Author Information
- Publication Type:Journal Article
- MeSH: Claudin-1; analysis; Claudin-4; analysis; Colorectal Neoplasms; chemistry; Disease Progression; Humans; Lymphatic Metastasis; Neoplasm Staging
- From: Chinese Journal of Gastrointestinal Surgery 2012;15(10):1073-1076
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of tight junction protein Claudin-1 and Claudin-4 in colorectal cancer tissues and its clinical significance.
METHODSImmunohistochemical staining detected the expression of tight junction protein Claudin-1 and Claudin-4 in 60 cases of colorectal cancer and 20 normal colorectal mucosa tissue. The clinical significance was analyzed.
RESULTSThe positive rates of Claudin-1 and Claudin-4 in colorectal cancer tissues were 76.6%(46/60) and 85.0%(51/60), significantly higher than 20.0% (4/20) and 30.0%(6/20) in the normal colorectal mucosa(both P<0.01). The positive rates of Claudin-1 and Claudin-4 were associated with tumor differentiation degree, lymph node metastasis and TNM staging(all P<0.05).
CONCLUSIONSThe high expression of the Claudin-1 and Claudin-4 may play a promoting role in colorectal cancer development and progression. Claudin-1 and Claudin-4 may become prognostic markers of colorectal cancer.
