Treatment of an infant with severe neonatal hypoxic-ischemic encephalopathy sequelae with transplantation of human neural stem cells into cerebral ventricle.
- Author:
Zuo LUAN
1
;
Guo-cai YIN
;
Xiao-hong HU
;
Su-qing QU
;
Nan-hai WU
;
Feng-qing YAN
;
Yang-ming QIAN
;
Hui-yu JIN
;
Xiao-jun GONG
Author Information
- Publication Type:Case Reports
- MeSH: Asphyxia Neonatorum; complications; Brain; pathology; physiopathology; Female; Humans; Hypoxia-Ischemia, Brain; etiology; pathology; physiopathology; therapy; Infant; Infant, Newborn; Injections, Intraventricular; Multipotent Stem Cells; transplantation; Neurons; Positron-Emission Tomography; Prognosis; Stem Cell Transplantation; methods; Time Factors; Treatment Outcome
- From: Chinese Journal of Pediatrics 2005;43(8):580-discussion 580
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVESevere newborn hypoxic-ischemic encephalopathy (HIE) has a very high rate of disability and no effective treatment is available. The present study aimed to preliminarily evaluate the effects of human neural stem cell transplantation in treatment of severe neonatal HIE.
METHODSThe patient was a 75-day old male infant with sequelae of severe HIE who had highly delayed development of intelligence and movement and myotonia. MRI showed multiple cerebromalacia and encephalatrophy. Cells obtained from the forebrain of an 11-week old fetus were cultured and amplified for 15 days. And then the human fetal neural stem cells were injected into cerebral ventricle of this infant.
RESULTSTwenty eight days after transplantation, remarkable improvement occurred not only in his myotonia but also in his intelligence and movement, which became similar to those of the normal infants of the same age. Positron emission tomography (PET) showed significantly increased radioactivity at temporal and occipital lobes which suggested that the cellular metabolism had increased greatly.
CONCLUSIONThe short-term effect of NSCs transplantation on the infant with severe HIE sequelae was significant. PET suggested that the implanted NSCs survived. Many more studies are needed to evaluate long-term effects of NSC transplantation in treatment of HIE.
