A fiber optic chemical sensor system for on-line monitoring the drug dissolution of rifampicin.
- Author:
Xin-xia LI
1
;
Yu-wen WANG
;
Yan WANG
;
Jian CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Antibiotics, Antitubercular; administration & dosage; chemistry; Automatic Data Processing; Capsules; Rifampin; administration & dosage; chemistry; Solubility
- From: Acta Pharmaceutica Sinica 2002;37(9):721-723
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study a continuous, on-line and automatic monitoring method for dissolution of drugs.
METHODSA new fiber optical chemical sensor prepared by sol-gel immobilization of molecular probe was reported. Based on multiple quenching of flurescence, an instrument and software system was designed to on-line monitor the drug dissolution of rifampicin.
RESULTSThe concentration of rifampicin was linear with ln(F0/F) when concentration was in the range of 10-170 micrograms/mL-1. The relative coefficient was 0.9993. The procession of dissolution can be on-line monitored. Parameters were obtained directly from the dissolution curve. There is no distinctly difference when compared with the method of the Pharmacopoeia of People's Republic of China (P > 0.05).
CONCLUSIONThis procession analysis can reflect the real dissolution of drug and obtain the total information.
