Effect of osthol on memory impairment of mice in AlCl3-induced acute senile model.
- Author:
Li-xia SHEN
1
;
Le-qun JIN
;
Dan-shen ZHANG
;
Gui-ping XUE
Author Information
- Publication Type:Journal Article
- MeSH: Acute-Phase Reaction; Aging; drug effects; metabolism; Aluminum Compounds; pharmacology; Animals; Avoidance Learning; drug effects; Brain; enzymology; Chlorides; pharmacology; Cnidium; chemistry; Coumarins; isolation & purification; pharmacology; therapeutic use; Female; Glutathione Peroxidase; blood; Male; Memory Disorders; chemically induced; enzymology; prevention & control; Mice; Plants, Medicinal; chemistry; Random Allocation; Superoxide Dismutase; metabolism
- From: Acta Pharmaceutica Sinica 2002;37(3):178-180
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the protective effect and mechanism of osthol on learning and memory impairment of mice with acute senile model induced by AlCl3.
METHODSAfter s.c. AlCl3 60 mg.kg-1 for 7 d and i.p. osthol 15 and 7.5 mg.kg-1 for 12 d, using step-through test and step-down test, the effect of osthol on learning and memory was observed and the glutathione peroxidase (GSH-PX) activities in blood and superoxide dismutase (SOD) activities in plasma and cerebrum were measured.
RESULTSOsthol 15 and 7.5 mg.kg-1 significantly improved the capability of memory and enhanced the activities of GSH-PX and SOD in AlCl3 treated mice.
CONCLUSIONOsthol shows protective effect on brain memory impairment of mice in acute senile model induced by AlCl3. Perhaps the mechanism is involved in enhancing the activities of GSH-PX and SOD, clearing away the free radical, protecting the brain neuron from the harm of lipoperoxide.
