Advances in the research of the role of mesenchymal stem cell in wound healing.
- Author:
Lingying LIU
1
;
Jiake CHAI
2
;
Yonghui YU
1
;
Yusen HOU
1
Author Information
1. Burn Institute, the First Hospital Affiliated to the PLA General Hospital, Beijing 100048, China.
2. Burn Institute, the First Hospital Affiliated to the PLA General Hospital, Beijing 100048, China. Email: cjk304@126.com.
- Publication Type:Journal Article
- MeSH:
Burns;
therapy;
Cell Differentiation;
Humans;
Mesenchymal Stem Cell Transplantation;
Mesenchymal Stromal Cells;
physiology;
Skin;
Wound Healing
- From:
Chinese Journal of Burns
2014;30(2):134-137
- CountryChina
- Language:Chinese
-
Abstract:
Wound healing is a dynamic and complicated process, which generally takes three overlapping phases: inflammation, proliferation, and remodeling. If wounds complicated by severe trauma, diabetes, vascular dysfunction disease, or a massive burn injury failed to pass through the three normal phases of healing, they might end up as chronic and refractory wounds. Mesenchymal stem cells (MSCs) play different important roles in the regulation of all the phases of wound healing. MSCs can be recruited into wound and differentiated into wound repair cells, as well as promote wound healing by exerting functions like anti-inflammation, anti-apoptosis, and neovascularization. This review focuses on the role and mechanism of MSCs in each phase of the wound healing process.
