Effects of cyclooxygenase 2 prostaglandin E2 induced by reactive oxygen species on wound healing.
- Author:
Yiping HU
1
;
Yifan ZHANG
1
;
Yunsong ZHANG
2
;
Min YAO
1
Author Information
1. Department of Burns and Plastic Surgery, Guangzhou Red Cross Hospital, Ji'nan University, Guangzhou 510220, China.
2. Department of Burns and Plastic Surgery, Guangzhou Red Cross Hospital, Ji'nan University, Guangzhou 510220, China. Email: yszhang5201314@163.com.
- Publication Type:Journal Article
- MeSH:
Cyclooxygenase 2;
metabolism;
Dinoprostone;
metabolism;
Reactive Oxygen Species;
metabolism;
Reverse Transcriptase Polymerase Chain Reaction;
methods;
Signal Transduction;
Wound Healing;
physiology
- From:
Chinese Journal of Burns
2014;30(3):254-257
- CountryChina
- Language:Chinese
-
Abstract:
Different from the previous knowledge regarding reactive oxygen species (ROS), recent research suggests that ROS play essential roles in initiating cascade reaction of wound healing. During wound healing, ROS can serve as the second messenger to regulate signal transduction and gene expression. In this paper, we review the mechanism of generation of cyclooxygenase 2-prostaglandin E2 induced by ROS, which regulates the early inflammatory response and subsequent healing after injury.
