Effects of Connexin Expression on Detrusor Overactivity in Male Patients with Bladder Outlet Obstruction Caused by Benign Prostatic Hyperplasia.
- Author:
Seung Hoon CHA
1
;
Joon Chul KIM
;
Tae Kon HWANG
Author Information
1. Department of Urology, The Catholic University of Korea, Seoul, Korea. kjc@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Benign prostatic hyperplasia;
Bladder;
Connexins
- MeSH:
Biopsy;
Connexin 43;
Connexins;
Humans;
Male*;
Prostate;
Prostatic Hyperplasia*;
RNA, Messenger;
RNA-Directed DNA Polymerase;
Urinary Bladder Neck Obstruction*;
Urinary Bladder*;
Urodynamics
- From:Korean Journal of Urology
2004;45(9):897-902
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Detrusor overactivity is frequently associated with bladder outlet obstruction, which may be related with increased electrical coupling. The effects of connexin 43(Cx43) and connexin 26(Cx26) mRNA expressions on the detrusor over activity were studied. MATERIALS AND METHODS: 36 male patients, with a bladder outlet obstruction due to benign prostatic hyperplasia(BPH), were subdivided into those with and without detrusor overactivity(DO) based on urodynamic studies: DO(+) and DO(-) group. All patients underwent a bladder biopsy during TUR-P. The symptoms, International Prostate Symptom Score (IPSS), prostate size, serum prostatic specific antigen(PSA) value and urodynamic parameters were compared between the two groups. The expressions of Cx43 and Cx26 mRNA in each group were analyzed by a reverse transcriptase polymerase chain reaction(RT-PCR). RESULTS: There were no differences in age, IPSS score, prostate volume, PSA and free Qmax between the DO(+) and DO(-) groups. The expressions of Cx43 and Cx26 mRNA in the DO(+) group were significantly increased compared with those in the DO(-) group. CONCLUSIONS: Our results show there is a change in the expressions of the Cx43 and Cx26 according to the bladder function, which may be related to detrusor overactivity in patients with a bladder outlet obstruction.
