Human umbilical cord mesenchymal stem cells and the treatment of spinal cord injury.
- Author:
Fu-jiang CAO
1
;
Shi-qing FENG
Author Information
- Publication Type:Journal Article
- MeSH: Humans; Mesenchymal Stromal Cells; cytology; physiology; Models, Biological; Spinal Cord Injuries; pathology; therapy; Stem Cell Transplantation; Umbilical Cord; cytology
- From: Chinese Medical Journal 2009;122(2):225-231
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo review the recent studies about human umbilical cord mesenchymal stem cells (hUCMSCs) and advances in the treatment of spinal cord injury. Data sources Published articles (1983 - 2007) about hUCMSCs and spinal cord injury were selected using Medline. Study selection Articles selected were relevant to development of mesenchymal stem cells (MSCs) for transplantation in spinal cord injury therapy. Of 258 originally identified articles 51 were selected that specifically addressed the stated purpose.
RESULTSRecent work has revealed that hUCMSCs share most of the characteristics with MSCs derived from bone marrow and are more appropriate to transplantation for cell based therapies.
CONCLUSIONSHuman umbilical cord could be regarded as a source of MSCs for experimental and clinical needs. In addition, as a peculiar source of stem cells, hUCMSCs may play an important role in the treatment of spinal cord injury.
