Evaluation of live attenuated S79 mumps vaccine effectiveness in mumps outbreaks: a matched case-control study.
- Author:
Chuan-xi FU
1
;
Jun NIE
;
Jian-hua LIANG
;
Ming WANG
Author Information
- Publication Type:Journal Article
- MeSH: Case-Control Studies; Child; Child, Preschool; China; epidemiology; Female; Humans; Infant; Male; Mumps; epidemiology; immunology; Mumps Vaccine; immunology; Vaccines, Attenuated; immunology
- From: Chinese Medical Journal 2009;122(3):307-310
- CountryChina
- Language:English
-
Abstract:
BACKGROUNDMumps virus infection is a potentially serious viral infection of childhood and early adulthood. In China, live attenuated S(79) mumps vaccine has been licensed for pediatric use since 1990. The objective of this study was to determine the effectiveness of live attenuated S(79) mumps vaccine against clinical mumps in outbreaks.
METHODSCases were selected from mumps outbreaks in schools in Guangzhou between 2004 and 2005. Each case was matched by gender, age and classroom. Vaccination information was obtained from Children's EPI Administrative Computerized System. Vaccine effectiveness (VE) was calculated for 1 or 2 doses of S(79) vaccine with 95% confidence intervals (CI).
RESULTSOne hundred and ninety-four cases and 194 controls were enrolled into the study. VE of the S(79) mumps vaccine for 1 dose versus 0 confer protection 80.4% (95% CI, 60.0%-90.4%) and VEs against mumps in outbreaks for 1 dose of mumps vaccine are similar among those children aged 4-9 years and aged over 10 years old.
CONCLUSIONThe live attenuated S(79) mumps vaccine can be effective in preventing clinical mumps outbreaks.
