Combination of balanced ultrafiltration with modified ultrafiltration attenuates pulmonary injury in patients undergoing open heart surgery.
- Author:
Huimin HUANG
1
;
Tingjun YAO
;
Wei WANG
;
Deming ZHU
;
Wei ZHANG
;
Hong CHEN
;
Weiding FU
Author Information
- Publication Type:Clinical Trial
- MeSH: Cardiac Surgical Procedures; Cardiopulmonary Bypass; methods; Child, Preschool; Heart Defects, Congenital; surgery; Humans; Lung Diseases; prevention & control; Pulmonary Edema; prevention & control; Ultrafiltration; methods
- From: Chinese Medical Journal 2003;116(10):1504-1507
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo explore the effects of ultrafiltration technique in preventing and relieving pulmonary injury in children undergoing open heart surgery and cardiopulmonary bypass (CPB).
METHODSThirty cases with congenital heart defects were divided into a control group and an experimental group. In the control group, conventional cardiopulmonary bypass was used without ultrafiltration; while in the experimental group, cardiopulmonary bypass with balanced ultrafiltration and modified ultrafiltration were used. Pulmonary static compliance (Cstat), airway resistance (Raw), alveolar-arterial oxygen difference (A-a DO2), hematocrit (HCT), serum albumin (Alb), interleukin-6 (IL-6), endothelia-1 (ET-1) and thromboxane (TXB2) were measured.
RESULTSThe pulmonary function was improved, HCT and serum albumin concentrations were increased, and some harmful medium-size solutes were decreased in the experimental groups compared with the control group.
CONCLUSIONSCombination of balanced ultrafiltration with modified ultrafiltration can effectively concentrate blood, exclude harmful inflammatory mediators, and attenuate lung edema and inflammatory responsive pulmonary injury.
