Research Progress on Notch Signal Pathway in Acute Graft-Versus-Host Disease -Review.
10.7534/j.issn.1009-2137.2017.01.053
- VernacularTitle:Notch信号通路参与急性移植物抗宿主病的研究进展
- Author:
Dong-Mei GUO
1
;
Ban-Ban LI
2
;
Chun-Pu LI
2
;
Qing-Liang TENG
2
Author Information
1. Department of Hematology, The Central Hospital of Taian, Taian 271000, Shandong Province, China .E-mail: dongmeiguo@aliyun.com.
2. Department of Hematology, The Central Hospital of Taian, Taian 271000, Shandong Province, China.
- Publication Type:Journal Article
- From:
Journal of Experimental Hematology
2017;25(1):291-295
- CountryChina
- Language:Chinese
-
Abstract:
The Notch signaling pathway is a highly conserved cell signaling system that plays an essential role in many biological processes. Notch signaling regulates multiple aspects of hematopoiesis, especially during T cell develop-ment. Recent data suggest that Notch also regulates mature T cell differentiation and function. The latest data show that Notch also plays an essential role in alloreactive T cells mediating acute graft-versus-host disease (aGVHD), the most severe complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Notch inhibition in donor-derived T cells or blockade of individual Notch ligands and receptors after transplantation can reduce GVHD severity and mortality in mouse models of allo-HSCT, without causing global immunosuppression. These findings indicate Notch in T cells as an attractive therapeutic target to control aGVHD. In this article, the pathophysiology of aGVHD, the Notch signal pathway and aGVHD are reviewed.
