Gene Polymorphism of Inflammation-related Cytokines Correlates with the Susceptibility to DLBCL.
- VernacularTitle:炎症相关因子基因多态性与弥漫大B细胞淋巴瘤的易感性研究
- Author:
Cai-Ping TIAN
1
;
Shi-Qi LIAO
1
;
Hong-Xia YUAN
1
;
Bo-Cheng YAO
1
;
Fang WANG
2
Author Information
- Publication Type:Journal Article
- From: Journal of Experimental Hematology 2017;25(2):444-448
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship of gene polymorphisms of inflammattion related cytokines with incidence of diffuse large B-cell lymphoma(DLBCL) in Gansu Han population.
METHODSThe gene polymorphism of inflammation-related cytokines were detected by high-resolution melting(HRM) curve.
RESULTSThe homozygous CC genotype carrying IL-1RA rs4251961 gene locus was related with the risk of DLBCL in comparison with homozygous TT, the OR was 0.83 of homozygous CC, 95% CI=0.697-0.997,P<0.05), while the C allele of IL-1RA rs4251961 gene locus significantly correlated with the high incidence of diffuse large B-cell lymphoma compared with T allele(OR=8.83, 95% CI=1.909-40.813,P<0.01).
CONCLUSIONThe minor allele C of IL-1RA rs4251961 gene locus significantly relates with the susceptibility to DLBCL.
