Association between polymorphisms of XPD gene and susceptibility to chronic benzene poisoning.
- Author:
Hui-long HUANG
1
;
Jian-ning XU
;
Quan-kai WANG
;
Ya-wen WANG
;
Min YANG
;
Yan CHEN
;
Gui-lan LI
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Benzene; poisoning; Case-Control Studies; Chronic Disease; Codon; genetics; Female; Genetic Predisposition to Disease; Humans; Male; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Xeroderma Pigmentosum Group D Protein; genetics
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2006;24(7):390-393
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship between genetic polymorphisms of XPD gene and susceptibility to chronic benzene poisoning.
METHODSA case control study was conducted. Eighty patients diagnosed with chronic benzene poisoning and 62 workers occupationally exposed to benzene who were engaged in the same working time and job title as patients were investigated. PCR-RFLP was used for detecting the single nucleotide polymorphisms (SNPs) on codon156, codon312 and codon751 of XPD gene.
RESULTSThere was a 2.903 times (95% CI: 1.054 - 7.959, P = 0.039 2) increased risk of chronic benzene poisoning in the subjects carrying XPD 751Gln variant allele compared with those carrying XPD 751Lys/Lys genotype, after adjusted for sex, length of service, smoking and drinking status.
CONCLUSIONThe subjects with XPD 751Gln variant allele are more susceptive to benzene.
