Relationship between polymorphisms of DNA repair gene XRCC1 and susceptibility to radiation injury.
- Author:
Liang-qun WANG
1
;
Xu-mei WU
;
Xue-yun FAN
;
Jin-de YAN
;
Yu-ping BAI
;
Ru-li LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Case-Control Studies; Chromosome Aberrations; DNA Repair; DNA-Binding Proteins; genetics; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Radiation Injuries; genetics; X-ray Repair Cross Complementing Protein 1
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2006;24(8):479-482
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship between polymorphisms of DNA repair gene XRCC1 and susceptibility to radiation injury.
METHODSIn 1:1 case-control study, 113 abnormal chromosome workers exposed to ionizing radiation were selected as cases and 113 normal chromosome as controls who matched with case for sex, age (+/- 5 years), nation, type of work, the same or more but in 2 years work length and the same similar levels of the cumulative exposure radiation dose. Genotypes were analysed using PCR based restriction fragment length polymorphism techniques.
RESULTSThe frequency of XRCC1 26304TT allele in case group (18.58%) was significantly higher than that in control group (7.08%), with OR for radiation damage being 3.47 (95% CI 1.43 - 8.44, P < 0.05). No association was observed between XRCC1 G27466A and G28152A and susceptibility to radiation injury.
CONCLUSIONThe mutation of XRCC1 C26304T is related with the susceptibility to radiation injury. The polymorphisms of XRCC1 G27466A and G28152A are not found to have association with abnormal chromosomes.
