The Adverse Effect of the 2-1-1 Regimen for Rabies PEP in Preschool Children.

Shu Qing Liu; Xiao Yan Tao; Peng Cheng YU; Chun Qiu Jin; Hong Jie YU; Mei Shun Chen; Wu Yang Zhu

Return

The Adverse Effect of the 2-1-1 Regimen for Rabies PEP in Preschool Children.

Author: Shu Qing LIU ¹ ; Xiao Yan TAO ¹ ; Peng Cheng YU ¹ ; Chun Qiu JIN ² ; Hong Jie YU ³ ; Mei Shun CHEN ² ; Wu Yang ZHU ¹
Author Information

1. Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
2. Wenling Center for Disease Control and Prevention, Wenling 317500, Zhejiang, China.
3. Division of Infectious Diseases, Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Publication Type:Letter
Keywords: 2-1-1 regimen; Essen regimen; PEP; Preschool children
MeSH: Child; Child, Preschool; Germany; Humans; Infant; Post-Exposure Prophylaxis; standards; Rabies; prevention & control; Rabies Vaccines; adverse effects; Vaccination; adverse effects
From: Biomedical and Environmental Sciences 2017;30(5):373-375
CountryChina
Language:English
Abstract: Post-exposure prophylaxis (PEP) has proved to be the most important measure for rabies prevention and control. There is little information regarding adverse reactions to the Essen and 2-1-1 regimens in preschool children (aged 0-6). We reexamined the outcomes of 1,109 preschool children who were vaccinated using SPEEDA under the Essen regimen between January 2011 and December 2012 and 1,267 preschool children under the 2-1-1 regimen between January 2013 and December 2014. We find that, in preschool children, the febrile reaction after the first 2-dose injection in the 2-1-1 regimen was significantly higher than that induced by the first 1-dose in the Essen procedure. Thus, we recommend that the Essen regimen should still be used for rabies PEP in preschool children.