Antimicrobial Susceptibility Testing and Molecular Characterization of Mycobacterium fortuitum Isolates in China.

Hui Wen Zheng; Yu Pang; Guang Xue HE; Yuan Yuan Song; Yan Lin Zhao

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Antimicrobial Susceptibility Testing and Molecular Characterization of Mycobacterium fortuitum Isolates in China.

Author: Hui Wen ZHENG ¹ ; Yu PANG ² ; Guang Xue HE ³ ; Yuan Yuan SONG ² ; Yan Lin ZHAO ²
Author Information

1. National institute for communicable disease control and prevention, Chinese center for disease control and prevention, Beijing 102206, China.
2. National Tuberculosis Reference Laboratory, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
3. Science and Technology Department, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Publication Type:Letter
Keywords: Genotype; Nontuberculosis; Phenotype; Susceptibility
MeSH: Antitubercular Agents; pharmacology; China; Drug Resistance, Bacterial; Microbial Sensitivity Tests; Mycobacterium fortuitum; drug effects
From: Biomedical and Environmental Sciences 2017;30(5):376-379
CountryChina
Language:English
Abstract: We performed molecular identification of clinical isolates of Mycobacterium fortuitum (M. fortuitum) and conducted drug susceptibility testing to analyze the in vitro susceptibility of clinical M. fortuitum isolates and potential molecular mechanism conferring resistance to fluoroquinolone and macrolide drugs. The results showed that moxifloxacin had the highest in vitro activity against M. fortuitum, and most M. fortuitum isolates were resistant to clarithromycin and linezolid in China. The loss of genetic mutation in clarithromycin- and amikacin-resistant isolates indicates that some other intrinsic mechanism conferring clarithromycin and amikacin resistance plays an essential role in M. fortuitum infection.